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. 2017 Oct 10;21(2):187–200. doi: 10.1093/ijnp/pyx083

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© The Author(s) 2017. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Treatment with interferon (IFN)-α, interferon-stimulated gene 15 (ISG15), and all proteins increase UBA7, UBE2L6, and HERC5 gene expression via activation of signal transducer and activator of transcription-1 (STAT1) protein. IFN-α (500 and 5000 pg/mL) increased UBA7 (a), UBE2L6 (b), and HERC5 (c) gene expression, whereas cotreatment with fludarabine prevented such upregulation (a-c). ISG15 and all proteins induced UBA7 (d), UBE2L6 (e), and HERC5 (f). Cotreatment with either ISG15 or all proteins and fludarabine prevented such increase (d-f). Three independent experiments were conducted on independent cultures (n=3). Data are shown as mean±SEM. One-way ANOVA, Newman–Keuls’ posthoc test ^**P<.01, ^***P<.001, ^****P<.0001, compared with vehicle treatment or as indicated.