Figure 3.

Social interaction deficits in susceptible mice were reversed by fluoxetine. Non-stress mice did not exhibit any significant differences in the amount of time in the interaction zone over the course of the experiment (Figure 3a). Susceptible mice exhibited less time interacting with the conspecific target on all 3 test days compared with control mice (Figure 3b). Following 7 days but not 24 hours of treatment with fluoxetine (10 mg/kg), social interaction scores of susceptible C57BL/6J mice were restored to a level comparable with control mice (***P<.001 compared with baseline values). No effect was observed with ketamine (10 mg/kg) or CERC-501 (1 mg/kg) treatment.