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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Cell Rep. 2018 Jan 16;22(3):624–637. doi: 10.1016/j.celrep.2017.12.071

Figure 5. A Tumor-Prone Gene Signature in the Colonic Epithelium of Aged Obese Mice.

Figure 5

(A and B) The results of Reactome pathway enrichment analysis are shown for up- (A) and downregulated genes (B) in aged obese mice. The Reactome hierarchical pathway structure is shown with color corresponding to the significance of p values. The darker color is more significant.

(C) The heatmap depicts the standardized expression levels of the 35 primary response genes in aged obese and control mice.

(D) Overlap of tumor suppressor genes (TSGs) with downregulated genes in aged obese mice. Overlap p value was calculated using hypergeometric test.

See also Figure S5 and Table S5.