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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Ann N Y Acad Sci. 2018 Jan;1412(1):154–165. doi: 10.1111/nyas.13535

Figure 2.

Figure 2

Immunoglobulin variable-region gene segment usage is skewed in MuSK MG repertoires. Heavy-chain V gene family usage variability for the naive and memory B cell compartments. Usage variability is represented by the repertoire dissimilarity index (RDI) for naive (Naive-IgM) and memory (Memory-IgG) V families (IGHV1 thru IGHV5) among healthy donors (HDs) and MuSK MG patients. Each point indicates a pairwise RDI score (y-axis) for two subjects, with the mean score for each set of subjects marked by a horizontal bar and a density estimate indicated by the shaded region. RDI scores are grouped by status comparisons for HD in blue and MuSK-MG (MuSK) in green. Adapted from Ref. 36.