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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Neurobiol Dis. 2017 Jul 12;106:191–204. doi: 10.1016/j.nbd.2017.07.007

Figure 4. Nortriptyline reduces accumulation of human α-syn in transgenic mice.

Figure 4

Six-month-old mice were treated for 30 days with vehicle (N=7), 0.5 mg/kg (N=6), 5 mg/kg (N=6), or 25 mg/kg (N=7) NOR. Treatment with NOR reduced the number of cells immunoreactive for human α-syn in both A. cortex and B. hippocampus. C & D. Representative sections from the hippocampus show reduced α-syn accumulation (green) in cell bodies and the neuropil without affecting neuronal architecture as judged by NeuN immunostaining (red). White arrows indicate hippocampal pyramidal cell layer; white asterisks indicate hippocampal neuropil. Data represent mean ± SEM. Statistical significance determined by one-way ANOVA with Dunnett’s post hoc test. *p ≤ 0.05, **p ≤0.01, *** p ≤ 0.001.