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. 2018 Feb 1;35(3):486–491. doi: 10.1089/neu.2015.3993

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Copyright 2018, Mary Ann Liebert, Inc.

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FIG. 2. — Cytotoxic response of oligodendrocyte precursor cells (OPCs) to endoplasmic reticulum (ER) stress. Wild type (WT) and activating transcription factor-6 (ATF6α)^-/- OPCs were treated with tunicamycin (Tm) as indicated. (A) Representative phase contrast micrographs depict declining density of ATF6α^-/- mouse OPCs (mOPCs). (B) MTT cell survival assay shows a decreased number of viable ATF6α^-/- mOPCs at all indicated time intervals. (C) Increased lactic dehydrogenase (LDH) release in ATF6α^-/- mOPCs suggests enhanced cell death in response to ER stress. Data (B,C) are the mean ± standard deviation (n = 4, * p < 0.05, ** p < 0.01).