Table 3.
Treatment‐related parameters in the treatment arm compared with those in the standard care arm
| Treatment arm | Standard care arm | P | |
|---|---|---|---|
| n = 20 | n = 100 | ||
| During hospitalization | |||
| Decrease in E/e′ | 6.48 (SD 2.92) | 2.62 (SD 4.67) | 0.001 |
| Decrease in IVCi (1–5) | 1.79 (SD 1.02) | 0.39 (SD 0.82) | <0.001 |
| % decrease in BNP (ng/L) | 35.9 (SD 26.3) | 16.6 (SD 61.1) | 0.029 |
| LOH (days) | 3.74 (SD 2.02) | 6.85 (SD 4.22) | 0.002 |
| Cumulative fluid loss (mL) | 5447 (SD 5364) | 3072 (SD 3059) | <0.001 |
| Decrease in eGFR (mL/min/1.73 m2) | 3.47 (SD 8.64) | 4.41 (SD 13.8) | 0.778 |
| On the day of discharge | |||
| Final E/e′ | 14.4 (SD 3.14) | 18.0 (SD 5.63) | 0.007 |
| Final IVCi (1–5) | 1.21 (SD 0.91) | 1.82 (SD 0.76) | 0.005 |
| Final BNP (ng/L) | 249 (172–408) | 426 (242–1015) | 0.011 |
| Pulmonary decongested on LUS | 80.0% | 53.0% | 0.039 |
| E/e′ <15 | 60.0% | 35.0% | 0.020 |
| Pulmonary decongestion or E/e′ < 15 | 95.0% | 63.0% | 0.007 |
| Asymptomatic at discharge | 95.0% | 72.0% | 0.036 |
| Final eGFR (mL/min/1.73 m2) | 58.3 (SD 24.2) | 51.9 (SD 23.8) | 0.287 |
| Adverse events | |||
| Acute kidney injury | 15.0% | 21.0% | 0.617 |
| Symptomatic hypotension | 0% | 4.0% | 0.378 |
BNP, brain natriuretic peptide; E/e′, medial E to e′ ratio; eGFR, estimated glomerular filtration rate; IVCi, inferior vena cava index (scale 1–5); LOH, length of hospitalization; LUS, lung ultrasound; SD, standard deviation. Bold means statistically significant.
Values are expressed as mean ± SD except for BNP expressed as median (25th–75th interquartile percentile). Categorical variables are expressed as number of cases (%).