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. 2018 Feb 1;14(2):e1007111. doi: 10.1371/journal.pgen.1007111

Table 1. Genome-wide significance thresholds.

Fitted distributions are stable enough for threshold determination after 100,000 to 300,000 simulations.

Pedigree 100k 200k 300k 1M
260 6.36x10-6 6.35x10-6 6.28x10-6 6.25x10-6
576834 3.50x10-6 3.53x10-6 3.53x10-6 3.51x10-6
571744 3.80x10-6 3.83x10-6 3.75x10-6 3.80x10-6
34955 5.67x10-6 5.60x10-6 5.61x10-6 5.61x10-6