Fig 2. Effects of oral administration of E. gracilis Z and paramylon on arthritis score in collagen-induced arthritis mouse model.

The arthritis-related condition of the extremities was evaluated three times per week. The total score of all four extremities was calculated as follows: 0: no evidence of erythema and swelling, 1: slight redness/swelling of one small joint such as phalangeal joint, 2: redness/swelling of two or more small joints, or a large joint, 3: redness/swelling of one extremity, and 4: maximum redness/swelling of the whole region of one extremity. Values are means ± standard deviation (SD) of five mice, *p < 0.05 compared to the control using Steel-Dwass test.