Table 2. Hepatic mRNA content and TG levels in mice with depleted n-3 PUFA.

	CT-1	DEF-1	CT-3	DEF-3
SREBP-1c	1.09 ± 0.15	1.65 ± 0.19*	1.03 ± 0.15	1.66 ± 0.32
FAS	1.04 ± 0.11	1.88 ± 0.08*	1.04 ± 0.16	2.37 ± 0.21*
SCD-1	1.21 ± 0.23	1.78 ± 0.37	1.02 ± 0.12	1.41 ± 0.08*
ACCα	1.08 ± 0.16	1.73 ± 0.21*	1.02 ± 0.10	1.53 ± 0.23*
Hepatic TG	91.44 ± 5.09	93.14 ± 11.05	86.03 ± 3.29	128.4 ± 13.58*

Hepatic content in TG (expressed as nmol/mg of protein) and in sterol-regulatory element binding protein-1c (SREBP-1c), fatty acid synthase (FAS), stearoyl-CoA desaturase 1 (SCD-1) and acetyl-CoA carboxylase α (ACCα) mRNA (expressed as relative expression) in mice fed a control (CT-1, n = 9; CT-3, n = 4) or an n-3 PUFA-depleted diet for one (DEF-1, n = 9) or three months (DEF-3, n = 7).

Data are the means ± SEM.

*p<0.05 versus CT mice (Student’s t-test).