Table 1. Genetic association of missense SNPs in KRT6A, KRT6B and KRT6C with dental caries in permanent dentition of adults (N = 573, 25–50 years) and primary dentition of children (N = 449, 6–12 years).
| Permanent | Primary | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Phenotype | β estimate | SE | p-value | Phenotype | β estimate | SE | p-value |
| KRT6A | rs17845411 (K6aN21S) |
DS | 1.527 | 2.454 | 0.0144 | ds | -0.126 | -0.563 | 0.5734 |
| DMFS | 3.502 | 2.505 | 0.0125 | dfs | -0.404 | -0.690 | 0.4904 | ||
| PF-DMFS | 0.818 | 1.983 | 0.0478 | pf-dfs | 0.013 | 0.049 | 0.9606 | ||
| rs62617089 (K6aR443W) |
DS | -2.968 | -1.423 | 0.1552 | ds | 0.3068 | 0.451 | 0.6522 | |
| DMFS | -7.3 | -1.557 | 0.1199 | dfs | -0.2014 | -0.1131 | 0.9100 | ||
| PF-DMFS | -1.337 | -0.9675 | 0.3337 | pf-dfs | -0.5381 | -0.6993 | 0.4847 | ||
| rs62617088 (K6aV532I/F) |
DS | -3.962 | -0.7643 | 0.4450 | ds | -1.15 | -0.6674 | 0.5048 | |
| DMFS | 24.88 | 2.142 | 0.0326 | dfs | 4.396 | 0.9748 | 0.3301 | ||
| PF-DMFS | 4.09 | 1.193 | 0.2334 | pf-dfs | 4.702 | 2.030 | 0.0430 | ||
|
KRT6C |
rs373213028 (K6cY62M/I) |
DS | -0.3984 | -0.7322 | 0.4643 | ds | -0.2299 | -1.178 | 0.2392 |
| DMFS | -0.7495 | -0.6127 | 0.5403 | dfs | -0.09136 | -0.1786 | 0.8583 | ||
| PF-DMFS | -0.04437 | -0.1233 | 0.9019 | pf-dfs | -0.1664 | -0.7417 | 0.4587 | ||
| rs411107 (K6cG88R) |
DS | -0.3576 | -0.6481 | 0.5172 | ds | -0.1539 | -0.7534 | 0.4516 | |
| DMFS | -0.6542 | -0.5273 | 0.5982 | dfs | 0.3151 | 0.589 | 0.5561 | ||
| PF-DMFS | -0.07503 | -0.2056 | 0.8372 | pf-dfs | 0.02438 | 0.1035 | 0.9176 | ||
| rs200653200 (K6cG97R) |
DS | 2.174 | 2.361 | 0.0186 | ds | 0.093 | 0.2671 | 0.7895 | |
| DMFS | 2.029 | 0.976 | 0.3294 | dfs | -0.564 | -0.618 | 0.5370 | ||
| PF-DMFS | 0.844 | 1.380 | 0.1680 | pf-dfs | -0.119 | -0.299 | 0.7651 | ||
| rs394598 (K6cG111D) |
DS | -0.07541 | -0.1363 | 0.8916 | ds | -0.1852 | -0.9114 | 0.3625 | |
| DMFS | -0.3352 | -0.2695 | 0.7876 | dfs | -0.2154 | -0.4046 | 0.6859 | ||
| PF-DMFS | 0.07602 | 0.2077 | 0.8355 | pf-dfs | -0.2583 | -1.11 | 0.2678 | ||
| rs151117600 (K6cS143N) |
DS | 1.552 | 2.479 | 0.0185 | ds | -0.091 | -0.403 | 0.6874 | |
| DMFS | 3.756 | 2.670 | 0.0078 | dfs | -0.449 | -0.763 | 0.4461 | ||
| PF-DMFS | 0.855 | 2.060 | 0.0399 | pf-dfs | -0.028 | -0.109 | 0.9133 | ||
| rs11608915 (K6cR182Q) |
DS | -0.7027 | -1.313 | 0.1897 | ds | 0.05696 | 0.31 | 0.7567 | |
| DMFS | -1.844 | -1.534 | 0.1257 | dfs | -0.05705 | -0.1186 | 0.9057 | ||
| PF-DMFS | -0.1604 | -0.4524 | 0.6512 | pf-dfs | -0.2227 | -1.068 | 0.2862 | ||
| rs412533 (K6cV481I) |
DS | -0.4038 | -0.7407 | 0.4592 | ds | -0.2487 | -1.281 | 0.2006 | |
| DMFS | -8959 | -0.7309 | 0.4651 | dfs | -0.08172 | -0.1606 | 0.8725 | ||
| PF-DMFS | -0.09512 | -0.2637 | 0.7921 | pf-dfs | -0.1556 | -0.697 | 0.4862 | ||
| Rs71453291 (K6cG538A) |
DS | -2.262 | -0.9653 | 0.3348 | ds | -1.169 | -1.397 | 0.163 | |
| DMFS | -6.548 | -1.243 | 0.2143 | dfs | -3.483 | -1.591 | 0.1123 | ||
| PF-DMFS | -0.5726 | -0.3688 | 0.7124 | pf-dfs | -1.396 | -1.514 | 0.1308 | ||
|
KRT6B |
rs428894 (K6bN21S) |
DS | -0.7057 | -1.32 | 0.1874 | ds | 0.2388 | 1.291 | 0.1972 |
| DMFS | -1.626 | -1.353 | 0.1766 | dfs | 0.2836 | 0.5851 | 0.5588 | ||
| PF-DMFS | -0.5035 | -1.426 | 0.1543 | pf-dfs | 0.1425 | 0.671 | 0.5026 | ||
| rs144860693 (K6bG97R) |
DS | 1.626 | 2.611 | 0.0093 | ds | -0.102 | -0.452 | 0.6512 | |
| DMFS | 3.434 | 2.452 | 0.0145 | dfs | -0.471 | -0.800 | 0.4242 | ||
| PF-DMFS | 0.809 | 1.958 | 0.0507 | pf-dfs | -0.041 | -0.161 | 0.8720 | ||
| rs61745883 (K6bG111D) |
DS | 0.7205 | 1.037 | 0.3000 | ds | -0.3064 | -1.123 | 0.2619 | |
| DMFS | -0.946 | -0.6055 | 0.5451 | dfs | 0.2102 | 0.294 | 0.7689 | ||
| PF-DMFS | -0.084 | -0.1826 | 0.8552 | pf-dfs | 0.07402 | 0.2365 | 0.8182 | ||
| rs28538343 (K6bS143N) |
DS | 2.404 | 3.574 | 0.0004 | ds | -0.106 | -0.451 | 0.6525 | |
| DMFS | 4.276 | 2.816 | 0.0050 | dfs | -0.387 | -0.631 | 0.5286 | ||
| PF-DMFS | 0.960 | 2.141 | 0.0327 | pf-dfs | -0.101 | -0.378 | 0.7058 | ||
| rs652423 (K6bN227S/I) |
DS | -0.05969 | -0.1027 | 0.9182 | ds | -0.2959 | -1.464 | 0.1438 | |
| DMFS | -0.1918 | -0.1469 | 0.8833 | dfs | -0.0427 | -0.08051 | 0.9359 | ||
| PF-DMFS | 0.01969 | 0.05124 | 0.9591 | pf-dfs | -0.1598 | -0.6853 | 0.4935 | ||
| rs61746354 (K6bY497C) |
DS | -0.265 | -0.213 | 0.8315 | ds | 1.047 | 2.182 | 0.0296 | |
| DMFS | -1.116 | -0.398 | 0.6905 | dfs | 2.917 | 2.322 | 0.0206 | ||
| PF-DMFS | -1.097 | -1.343 | 0.1797 | pf-dfs | 1.742 | 3.152 | 0.0017 | ||
| rs61746355 (K6bG499S) |
DS | -3.274 | -1.395 | 0.1636 | ds | 0.2434 | 0.2896 | 0.7723 | |
| DMFS | 0.2415 | 0.04569 | 0.9636 | dfs | -0.03597 | -0.01634 | 0.987 | ||
| PF-DMFS | 1.947 | 1.253 | 0.2109 | pf-dfs | -0.1073 | -0.1114 | 0.9114 | ||
Note: All models are adjusted for age and sex.
DS and ds, Number of tooth surfaces with untreated decay; DMFS and dfs, number of decayed, missing
due to decay, and filled surfaces; PF-DMFS and pf-dfs, partial DMFS and dfs limited to molars and premolars pit and fissure surfaces.