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. 2018 Jan 22;14(1):e1006802. doi: 10.1371/journal.ppat.1006802

Fig 1. Small RNA-Seq analysis and miRNA expression levels in the FC and CB of sCJD.

Fig 1

(A) Relative quantitation of regulated miRNAs in the FC and CB of sCJD MM1 and VV2 subtypes compared to age and gender matched controls by small RNA-Seq. For FC 13 controls, 11 sCJD MM1 and 13 sCJD VV2 were analyzed. For CB: 12 controls, 12 sCJD MM1 and 9 sCJD VV2 were analyzed. Differential expression in miRNA sequencing data was evaluated with the DESeq2 tool and significantly differently expressed miRNAs were detected according to an adjusted p value of <0.05. Data represent log2 fold change for each comparison. log2 fold change was >0.5 for upregulated miRNAs and <-0.5 for downregulated miRNAs. MA plots are also supplied for data visualization (S1 Fig). (B) Venn diagram of subtype-dependent altered miRNA in the FC and CB of sCJD by small RNA-Seq. Percentage of maximal coincidence (percentage of maximal number of miRNAs that can be coincident between groups) is indicated.