Table 3.
Left Ventricular Structural Parameters and Fractional Volume of Surviving Cardiac Myocytes in the Transmural Myocardial Infarction Scars.
| n | 4wkMI |
8wkMI |
12wkMI |
|---|---|---|---|
| 6 | 6 | 5 | |
| Infarct size (% of LVFW) | 64.9 ± 11.8 | 63.3 ± 10.1 | 61.6 ± 6.4 |
| LV weight/BW ratio (mg/g) | 2.23 ± 0.29 | 2.38 ± 0.21 | 2.51 ± 0.31 |
| LV CSA (mm2) | 100.5 ± 16.8 | 108.9 ± 11.6 | 114.9 ± 15.8 |
| LV cavity CSA (mm2) | 48.9 ± 9.8 | 50.5 ± 4.5 | 55.3 ± 14.4 |
| Septal wall thickness (mm) | 1.80 ± 0.32 | 1.98 ± 0.34 | 2.14 ± 0.56 |
| Scar thickness (mm) | 0.88 ± 0.16 | 0.93 ± 0.30 | 0.92 ± 0.22 |
| Scar thinning ratio | 0.49 ± 0.09 | 0.48 ± 0.16 | 0.47 ± 0.17 |
| Expansion index | 1.02 ± 0.25 | 1.07 ± 0.36 | 1.12 ± 0.34 |
| Scar CSA, mm2 | 12.9 ± 2.7 | 11.6 ± 2.9 | 14.5 ± 2.4 |
| Surviving CM per scar, % | 3.6 ± 1.2 (1.7–5.7) | 3.4 ± 1.3 (1.8–5.1) | 2.5 ± 0.9 (1.2–4.1) |
Values are Mean ± SD; Scar thinning ratio = scar thickness/septal wall thickness; Expansion index = (LV cavity CSA/LV CSA) × (septal wall thickness/scar thickness). Abbreviations: n, number of rats; MI, myocardial infarction; LVFW, left ventricular free wall; LV, left ventricular; BW, body weight; CSA, cross-sectional area; CM, cardiac myocytes.