Extended Data Figure 9. Amino acid alignment of naturally occurring and de novo group II TCRs.

Amino acid alignment presents first the TCRβ chain followed the TCRα chain for naturally occurring group II natural TCRs n1–n10 from Fig. 5b (n denotes natural) and de novo TCRs De9–De18 from Fig. 5e. All segment identities are reported for each sequence in the sequence headers. Positional conservation is coloured as dark blue if conserved, and light blue or white if variable.