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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Adv Mater. 2017 Nov 2;29(47):10.1002/adma.201703969. doi: 10.1002/adma.201703969

Figure 3.

Figure 3

Delivery of antigen and adjuvant to immune cells. a) Uptake kinetics of dye-labeled CpG-CCNPs by BMDCs (n = 3; mean ± SD). b) Uptake kinetics of dye-conjugated CpG in free form or within CpG-CCNPs by BMDCs (n = 3; mean ± SD). c,d) Secretion of the pro-inflammatory cytokines IL-6 (c) and IL-12p40 (d) by BMDCs when incubated with either free CpG or CpG-CCNPs (n = 3; mean ± SD). e) Confocal microscopy colocalization of CpG and membrane proteins upon uptake of dual-labeled CpG-CCNPs by a BMDC. Green = CpG, red = membrane, blue = cell nucleus; scale bar = 10 µm. f) Uptake of dye-labeled CpG-CCNPs by different immune cell subsets in the draining lymph node after in vivo administration (n = 6; mean ± SD).