TABLE 1.
CORIN variants in normal and hypertensive individuals
| c. notation | p. notation | Exon | Major allele | Minor allele | Normal (n = 300) n (%) |
HP (n = 401) n (%) |
P value |
|---|---|---|---|---|---|---|---|
| c.102_103insA | p.(Ser4ValfsTer26) | 1 | no A | extra A | 2 (0.7) | 23 (5.7) | 0.0003 |
| c.131A > G | p.(Tyr13Cys) | 1 | A | G | 153 (51) | 176 (43.9) | 0.063 |
| c.376G > T | p.(Asp95Tyr) | 3 | G | T | 2 (0.7) | 2 (0.5) | 0.435 |
| c.1094T > G | p.(Leu334Trp) | 7 | T | G | 3 (1) | 5 (1.2) | 0.761 |
| c.1139G > A | p.(Arg349His) | 8 | G | A | 0 (0) | 1 (0.25) | 1 |
| c.1667G > A | p.(Arg525His) | 11 | G | A | 109 (36.3) | 145 (36.2) | 0.962 |
| c.1683G > T | p.(Arg530Ser) | 11 | G | T | 1 (0.3) | 10 (2.5) | 0.023 |
| c.2689C > T | p.(Pro866Ser) | 20 | C | T | 0 (0) | 1 (0.25) | 1 |
| c.2864C > T | p.(Thr924Met) | 20 | C | T | 0 (0) | 1 (0.25) | 1 |
Notes: CORIN sequence is based on NM_006587.2; HP: hypertensive individuals; n (%): number and percentage of minor allele.