TABLE 2.
Lipid changes by class in diabetic plasma, kidney, nerve, and retina
| Lipid Class | Plasma | Kidney | Nerve | Retina | ||||
| Increase | Decrease | Increase | Decrease | Increase | Decrease | Increase | Decrease | |
| CE | 7.1% (1) | 7.1% (1) | 9.1% (1) | 0% (0) | 0% (0) | 0% (0) | 0% (0) | 0% (0) |
| CerP | 0% (0) | 16.7% (1) | 0% (0) | 0% (0) | 0% (0) | 0% (0) | 0% (0) | 0% (0) |
| CL | 12.7% (7) | 3.6% (2) | 17.2% (15) | 11.5% (10) | 10.7% (3) | 0% (0) | 0% (0) | 7.1% (2) |
| DAG | 20.0% (7) | 0% (0) | 25.0% (14) | 1.8% (1) | 66.7% (32) | 0% (0) | 0% (0) | 29.2% (14) |
| FFA | ND | ND | ND | ND | 56.3% (9) | 6.3% (1) | 0% (0) | 37.5% (6) |
| LPC | 4.3% (1) | 60.9% (14) | 13.0% (3) | 13.0% (3) | 33.3% (8) | 20.8% (5) | 0% (0) | 39.1% (9) |
| LysoPE | 11.8% (2) | 11.8% (2) | 5.9% (1) | 11.8% (2) | 0% (0) | 30.0% (6) | 0% (0) | 5.0% (1) |
| MAG | 18.2% (2) | 0% (0) | 20.0% (2) | 0% (0) | 0% (0) | 0% (0) | 25.0% (1) | 0% (0) |
| PA | 0% (0) | 6.3% (1) | 23.8% (5) | 9.5% (2) | 20.0% (4) | 0% (0) | 0% (0) | 0% (0) |
| PC | 6.2% (5) | 34.6% (28) | 7.0% (7) | 24.0% (24) | 46.2% (36) | 1.3% (1) | 2.6% (2) | 2.6% (2) |
| PE | 16.3% (7) | 7.0% (3) | 12.3% (8) | 15.4% (10) | 66.7% (34) | 0% (0) | 5.9% (3) | 7.8% (4) |
| PG | 0% (0) | 0% (0) | 2.9% (1) | 22.9% (8) | 29.6% (8) | 3.7% (1) | 0% (0) | 10.0% (3) |
| PI | 6.7% (1) | 20.0% (3) | 6.7% (1) | 20.0% (3) | 20.0% (3) | 6.7% (1) | 0% (0) | 0% (0) |
| Plasmenyl-PC | 11.1% (2) | 33.3% (6) | 22.2% (2) | 0% (0) | 0% (0) | 0% (0) | 0% (0) | 0% (0) |
| Plasmenyl-PE | 28.0% (7) | 24.0% (6) | 25.9% (7) | 11.1% (3) | 44.8% (13) | 6.9% (2) | 3.2% (1) | 19.4% (6) |
| PS | 0% (0) | 0% (0) | 26.3% (5) | 0% (0) | 51.4% (19) | 0% (0) | 2.9% (1) | 8.8% (3) |
| SM | 36.0% (9) | 12.0% (3) | 34.6% (9) | 3.8% (1) | 47.8% (11) | 0% (0) | 9.1% (2) | 4.5% (1) |
| TAG | 5.6% (6) | 5.6% (6) | 6.7% (7) | 0% (0) | 71.1% (59) | 2.4% (2) | 0% (0) | 0% (0) |
Percent and total number (in parentheses) of members of lipid classes that were significantly different in 24-week-old db/db compared with db/+ mice. P < 0.01 based on a two-sample t-test with FDR correction, n = 10 per group. CerP, ceramide-1-phosphate; ND, not determined. Trends are summarized in supplemental Table S5.