Table 3. Diagnostic performance for SM-d cancer using non-extension sign for each macroscopic type.

	Sensitivity, % (95 % CI)	Specificity, % (95 % CI)	PPV, % (95 % CI)	NPV, % (95 % CI)	Accuracy, % (95 % CI)
0-Is	65.0 (55.3 – 69.8)	97.1 (93.4 – 99.0)	89.7 (76.3 – 96.3)	87.8 (84.5 – 89.5)	88.2 (82.8 – 90.9)
0-Isp	54.5 (35.8 – 54.5)	100 (94.9 – 100)	100 (65.7 – 100)	88.9 (84.3 – 88.9)	90.2 (82.1 – 90.2)
0-IIa	61.1 (44.9 – 68.9)	95.5 (88.8 – 98.6)	84.6 (62.2 – 95.4)	85.7 (79.8 – 88.6)	85.5 (76.1 – 90.0)
0-IIc · IIa + IIc · IIc + IIa	74.2 (63.1 – 81.2)	85.2 (72.4 – 93.3)	85.2 (72.4 – 93.3)	74.2 (63.1 – 81.2)	79.3 (67.4 – 86.9)

SM-d, submucosal invasion depth > 1000 μm; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.