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. Author manuscript; available in PMC: 2018 Jul 15.
Published in final edited form as: Biochem Pharmacol. 2017 Mar 29;136:99–108. doi: 10.1016/j.bcp.2017.03.018

Figure 2.

Figure 2

Binding and signaling profiles of GLP-1 and α- and α/β-peptides P1 – P9 in FlpInCHO cells stably expressing the human GLP-1R. Concentration-response curves for (A) GLP-1R binding, (B) cAMP accumulation, (C) Ca2+ mobilization, (D) ERK1/2 phosphorylation, (E) β-Arrestin-1 recruitment, and (F) β-Arrestin-2 recruitment. Data are normalized to the maximum response elicited by GLP-1 in each assay, and analyzed using a three-parameter logistic equation. Values are the mean + S.E.M. of three to four individual experiments, conducted in duplicate.