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. Author manuscript; available in PMC: 2018 Jul 15.
Published in final edited form as: Biochem Pharmacol. 2017 Mar 29;136:99–108. doi: 10.1016/j.bcp.2017.03.018

Figure 4.

Figure 4

Comparison of the bias factors for α- and α/β-peptides P1 – P9 relative to GLP-1 for β-Arrestin-1 recruitment versus cAMP accumulation between FlpInCHO cells (A) and HEK293 cells24 (B) and for β-Arrestin-2 recruitment versus cAMP accumulation between FlpInCHO cells (C) and HEK293 cells24 (D). Changes in log (τ/KA) were calculated to provide a measure of the degree of stimulus bias exhibited between different signaling pathways relative to that of the reference agonist GLP-1. * statistically significant difference from GLP-1 using one way analysis of variance followed by Dunnett’s test (P<0.05).