Table 4. Genotype and allele frequency of EZH2 rs12670401, EZH2 rs6464926, and SMYD3 VNTR between the case and control groups.
| Genotype/allele | Case group, n (%) | Control group, n (%) | χ2 | P | OR (95% CI) |
|---|---|---|---|---|---|
| EZH2 rs12670401 | |||||
| TT | 232 (32.58) | 290 (37.04) | 1 | ||
| TC | 323 (45.37) | 372 (47.51) | 0.495 | 0.482 | 1.085 (0.864–1.363) |
| CC | 157 (22.05) | 121 (15.45) | 12.22 | <0.001 | 1.687 (1.257–2.265) |
| TC + CC | 480 (67.42) | 493 (62.96) | 3.254 | 0.071 | 1.217 (0.983–1.507) |
| T | 787 (55.27) | 952 (60.79) | 1 | ||
| C | 637 (44.73) | 614 (39.21) | 9.356 | 0.002 | 1.255 (1.085–1.452) |
| EZH2 rs6464926 | |||||
| CC | 243 (34.13) | 305 (38.95) | 1 | ||
| CT | 327 (45.93) | 365 (46.62) | 1.044 | 0.307 | 1.124 (0.898–1.408) |
| TT | 142 (19.94) | 113(14.43) | 8.972 | 0.003 | 1.577 (1.169–2.127) |
| CT + TT | 469 (65.87) | 478 (61.05) | 3.737 | 0.053 | 1.232 (0.997–1.521) |
| C | 813 (57.09) | 975 (62.26) | 1 | ||
| T | 611 (42.91) | 591 (37.74) | 8.286 | 0.004 | 1.240 (1.071–1.435) |
| SMYD3VNTR | |||||
| 2/2 | 427 (59.97) | 483 (61.69) | 1 | ||
| 2/3 | 222 (31.18) | 289 (36.91) | 1.596 | 0.207 | 0.869 (0.699–1.081) |
| 3/3 | 63 (8.85) | 11 (1.40) | 39.971 | <0.001 | 6.478 (3.369–12.456) |
| 2/3 + 3/3 | 285 (40.03) | 300 (38.31) | 0.459 | 0.498 | 1.075 (0.873–1.323) |
| 2 | 1076 (75.56) | 1255 (80.14) | 1 | ||
| 3 | 348 (24.44) | 311 (19.86) | 9.1 | 0.003 | 1.305 (1.097–1.552) |