Table 9. Multivariate survival analysis of OS using Cox’s regression model for breast cancer patients.
Genotypes | B | S.E.M. | OR | 95% CI | P |
---|---|---|---|---|---|
EZH2 rs12670401 | 1.004 | 0.277 | 2.729 | 1.586–4.695 | <0.001 |
EZH2 rs6464926 | 0.928 | 0.275 | 2.529 | 1.474–4.339 | 0.001 |
SMYD3VNTR | 0.358 | 0.184 | 1.431 | 0.998–2.051 | 0.052 |
EZH2 mRNA | 0.463 | 0.219 | 1.589 | 1.034–2.440 | 0.035 |
SMYD3mRNA | 0.614 | 0.198 | 1.848 | 1.253–2.726 | 0.002 |
EZH2 protein | 0.574 | 0.198 | 1.776 | 1.205–2.617 | 0.004 |
SMYD3 protein | 0.495 | 0.191 | 1.640 | 1.128–2.385 | 0.010 |
Age | −0.172 | 0.528 | 0.842 | 0.299–2.372 | 0.745 |
Age of menarche | 0.158 | 0.205 | 1.171 | 0.783–1.750 | 0.443 |
Menopausal status | 0.594 | 0.471 | 1.810 | 0.720–4.553 | 0.207 |
Tumor size | 0.012 | 0.142 | 1.012 | 0.767–1.336 | 0.931 |
ER (+) | −0.247 | 0.766 | 0.781 | 0.174–3.504 | 0.747 |
PR (+) | 0.319 | 0.832 | 1.376 | 0.269–7.034 | 0.701 |
Histology | −0.049 | 0.151 | 0.952 | 0.708–1.281 | 0.746 |
Clinical staging | 1.193 | 0.237 | 3.298 | 2.072–5.249 | <0.001 |
Lymph node metastasis | 0.742 | 0.223 | 2.101 | 1.358–3.251 | 0.001 |
HER2 status | 1.204 | 0.255 | 3.335 | 2.024–5.494 | <0.001 |
FDRs with breast cancer | −0.125 | 0.190 | 0.883 | 0.608–1.282 | 0.513 |
Subtypes of breast cancer | −0.088 | 0.287 | 0.915 | 0.522–1.606 | 0.758 |
Metastasis situation | 0.668 | 0.189 | 1.950 | 1.345–2.826 | <0.001 |
Abbreviation: B, regression coefficient.