Table 4. The genotypic and allelic frequencies of TNF-α gene polymorphisms between spinal tuberculosis and controls.

	Patients (n=240) N (%)	Control (n=150) N (%)	Adjusted P	Adjusted OR	95% CI
TNF-238
Genotype
GG	217 (90.42%)	143 (95.33%)	Ref	1.00	Ref
GA	23 (9.58%)	7 (4.67%)	0.525	1.14	0.79–1.54
AA	0 (0)	0 (0)	NA	NA	NA
GA + AA	23 (9.58%)	7 (4.67%)	0.154	1.62	0.95–1.67
Allele
G	457 (95.21%)	293 (97.67%)	Ref	1.00	Ref
A	23 (4.79%)	7 (2.33%)	0.512	1.75	0.80–1.58
TNF-224
Genotype
GG	240 (100%)	150 (100%)	NA	NA	NA
GA	0 (0)	0 (0)	NA	NA	NA
AA	0 (0)	0 (0)	NA	NA	NA
GA + AA	0 (0)	0 (0)	NA	NA	NA
Allele
G	480 (100%)	300 (100%)	NA	NA	NA
A	0 (0)	0 (0)	NA	NA	NA
TNF-863
Genotype
CC	178 (74.17%)	108 (72.00%)	Ref	1.00	Ref
CA	54 (22.50%)	42 (28.00%)	0.254	1.21	0.77–1.04
AA	8 (3.33%)	0 (0)	0.375	1.14	0.75–1.01
CA + AA	62 (25.83%)	42 (28.00%)	0.275	1.17	0.78–1.24
Allele
C	410 (85.42%)	258 (86.00%)	Ref	1.00	Ref
A	70 (14.58%)	42 (14.00%)	0.385	1.05	0.81–0.94
TNF-857
Genotype
CC	132 (55.00%)	172 (84.67%)	Ref	1.00	Ref
CT	108 (45.00%)	26 (17.33%)	<0.001	8.85	2.42–30.84
TT	0 (0)	3 (2.00%)	0.245	2.35	0.21–3.54
CT + TT	108 (45.00%)	29 (19.33%)	<0.001	9.87	2.55–34.85
Allele
C	372 (77.50%)	268 (89.33%)	Ref	1.00	Ref
T	108 (22.50%)	32 (10.67%)	0.001	7.54	2.54–25.87
TNF-308
Genotype
GG	21790.42%)	127 (84.67%)	Ref	1.00	Ref
GA	23 (9.58%)	23 (15.33%)	0.412	1.07	0.86–1.05
AA	0 (0)	0 (0)	NA	NA	NA
GA + AA	23 (9.58%)	23 (15.33%)	0.211	1.54	0.95–1.38
Allele
G	457 (95.21%)	277 (92.33%)	Ref	1.00	Ref
A	23 (4.79%)	23 (7.67%)	0.387	1.41	0.87–1.27