Table 2.
Regional differences in cerebral blood flow.
| Absolute Cerebral Blood Flow (in mL/100g/min) |
Relative Cerebral Blood Flowa | |||||||
|---|---|---|---|---|---|---|---|---|
| Preterm Infants (n=98) |
Full-term Infants (n=104) |
Mean differenceb |
Preterm Infants (n=98) |
Full-term Infants (n=104) |
Mean differenceb |
|||
| Unadjusted mean ± SD | Unadjusted mean ± SD | Adjusted mean differenceb [95% CI] | Adjusted p-valueb | Unadjusted mean ± SD | Unadjusted mean ± SD | Adjusted mean differenceb [95% CI] | Adjusted p-valueb | |
| Sensorimotor cortex | 31.05 ± 5.4 | 20.26 ± 5.4 | 12.36 [5.99; 18.72] | <0.0001 | 1.6 ± 0.2 | 1.5 ± 0.3 | 0.03 [−0.17;0.24] | 1.00 |
| Auditory cortex | 23.05 ± 5.5 | 18.51 ± 3.6 | 6.1 [0.49;11.71] | 0.017 | 1.22 ± 0.2 | 1.41 ± 0.3 | −0.23 [−0.42;−0.04] | 0.0036 |
| Visual cortex | 23.73 ± 6.1 | 14.9 ± 3.8 | 10.38 [4.7; 16.04] | <0.0001 | 1.24 ± 0.2 | 1.13 ± 0.2 | 0.08 [−0.11; 0.27] | 0.998 |
| Superior medial prefrontal cortex | 22.6 ± 4.8 | 16.76 ± 3.8 | 7.42 [1.88;12.97] | 0.0004 | 1.19 ± 0.2 | 1.26 ± 0.2 | −0.03 [−0.29;0.07] | 1.0 |
| Dorsolateral prefrontal cortex | 17.32 ± 4.7 | 11.97 ± 3.2 | 6.91 [1.45; 12.38] | 0.0013 | 0.9 ± 0.2 | 0.9 ± 0.2 | −0.03 [−0.19; 0.14] | 1.00 |
| Anterior cingulate cortex | 27.77 ± 5.7 | 22.39 ± 4.5 | 6.93 [1.2; 12.67] | 0.0031 | 1.48 ± 0.3 | 1.7 ± 0.3 | −0.26 [−0.48;−0.05] | 0.0026 |
| Posterior cingulate cortex | 23.05 ± 6.4 | 16.44 ± 5 | 8.17 [2.32,14] | 0.0002 | 1.2 ± 0.2 | 1.23 ± 0.3 | −0.06 [−0.26;0.13] | 0.999 |
| Insula | 31.69 ± 6.2 | 28.11 ± 5.2 | 5.14 [−0.69;10.98] | 0.171 | 1.68 ± 0.2 | 2.15 ± 0.4 | − 0.51 [−0.73;-0.28] | <0.0001 |
| Lateral posterior parietal cortex | 24.16 ± 6.3 | 16.72 ± 4.3 | 8.99 [3.23;14.76] | <0.0001 | 1.26 ± 0.2 | 1.25 ± 0.2 | −0.03 [−0.21;0.14] | 1.0 |
| Basal ganglia | 35.73 ± 8.7 | 23.62 ± 5.8 | 13.67 [7.3;19.96] | <0.0001 | 1.86 ± 0.2 | 1.78 ± 0.3 | 0.05 [−0.16; 0.25] | 1.0 |
| Thalamus | 38.5 ± 10.9 | 25.19 ± 7.1 | 14.87 [7.95; 21.79] | <0.0001 | 2.01 ± 0.3 | 1.89 ± 0.4 | 0.07 [−0.17; 0.31] | 1.0 |
| Brainstem | 46.81 ± 13.8 | 32.23 ± 9.5 | 24.75 [17.53;31.97] | <0.0001 | 2.46 ± 0.6 | 2.46 ± 0.7 | −0.11 [−0.39;0.34] | 0.845 |
a
Relative regional CBF was defined as the ratio of the absolute CBF of one ROI over the global CBF
b
The adjusted mean difference (preterm – full-term) and corresponding p-values are based on the mixed linear model in which group (preterm vs. full-term), brain regions, sex, gestational age at birth, day of life at MRI and the interaction between group and regions of interest are the fixed effects. The p-values are adjusted for multiple comparisons (Tukey-Kramer).