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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J Invest Dermatol. 2017 Sep 20;138(2):325–335. doi: 10.1016/j.jid.2017.09.011

Figure 2. Lymphatic injury increases proliferation and activation of natural Tregs.

Figure 2

a) Representative FACS plots (upper) and quantification (lower) of proliferating (EdU+) TCR-β+Foxp3-GFP+ Tregs in mouse forelimbs (n=6/group).

b) Representative FACS plots of TCR-β+Foxp3-GFP+ Tregs in mouse blood (upper) and spleens (lower).

c) Representative FACS plots (left) and quantification (right) of TCR-β+Foxp3-GFP+Nrp-1+ nTregs and TCR-β+Foxp3-GFP+Nrp-1− iTregs in mouse forelimbs (n=5/group).

Mice harvested six weeks after surgery. Data expressed as mean ± SD. Statistically significant differences represented by *P<0.05, **P<0.01, and ***P<0.001. nTregs, natural Tregs; iTregs, induced Tregs.