Table 2.
Summary of volume measurement differences
| A. VOLUMES | Time-point 1 MRI | Time-point 2 MRI | Time-point 3 MRI |
|---|---|---|---|
| MGH-3DQI - NCI-3DQI | |||
| Volume difference: Median (range) – ml* |
−0.5 (−444.3 to 153.2) P=0.45 |
−4.2 (−312.1 to 323.6) P=0.42 |
−19.9 (−767.9 to 41.9) P=0.035 |
| *Corresponding relative volume difference - % of mean (PN ID) | 0.1 (PN13) 15.9 (PN1); 16.2 (PN14) |
2.4 (PN10) 20.3 (PN7); 22.0 (PN14) |
0.9 (PN6) 21.8 (PN15); 19.0 (PN12) |
| Relative volume difference Median (range) - % of mean** |
5.7 (0.1 to 21.2) | 5.0 (1.3 to 22.0) | 4.3 (0.3 to 21.8) |
| **Corresponding absolute volume difference - ml (PN ID) | 103.8 (PN15) 0.5 (PN13); 85.0 (PN5) |
10.4 (PN12) 8.7 (PN2); 323.6 (PN14) |
205.7 (PN1) 2.4 (PN2); 767.9 (PN15) |
| Number of PN with <20% relative volume difference | 14 | 13 | 13 |
| NCI-3DQI - NCI-MEDx | |||
| Volume difference: Median (range) – ml* |
−21.0 (−289.0 to 32.0) P=0.071 |
−47.0 (−406.0 to 29.0) P=0.0024 |
−21.0 (−227.0 to 114.0) P=0.018 |
| *Corresponding relative volume difference - % of mean (PN ID) | 15.4 (PN4) 9.2 (PN1); 3.8 (PN14) |
4.2 (PN13) 24.7 (PN1); 2.2 (PN14) |
13.2 (PN4) 10.4 (PN7); 3.9 (PN14) |
| Relative volume difference Median (range) - % of mean** |
7.7 (0.6 to 28.4) | 4.5 (0.3 to 24.7) | 4.3 (0.4 to 16.0) |
| **Corresponding absolute volume difference - ml (PN ID) | 48.0 (PN2) 0.5 (PN11); 147.0 (PN5) |
8.0 (PN8) 1.0 (PN9); 145.0 (PN5) |
50.0 (PN13) 10.0 (PN6); 114.0 (PN5) |
| Number of PN with <20% relative volume difference | 14 | 14 | 15 |
| MGH-3DQI - NCI-MEDx | |||
| Volume difference: Median (range) – ml* |
−10.0 (−733.3 to 185.2) P=0.21 |
−70.3 (−442.1 to 352.6) P=0.015 |
−29.9 (−781.9 to 47.9) P=0.010 |
| *Corresponding relative volume difference - % of mean (PN ID) | 6.4 (PN10) 25.0 (PN1); 19.9 (PN14) |
9.8 (PN2) 27.6 (PN7); 24.2 (PN14) |
1.3 (PN6) 22.2 (PN15); 22.0 (PN12) |
| Relative volume difference Median (range) - % of mean** |
6.4 (0.1 to 48.8) | 9.8 (3.0 to 44.0) | 9.5 (1.0 to 37.5) |
| **Corresponding absolute volume difference - ml (PN ID) | 10.0 (PN10) 1.0 (PN3); 232.0 (PN5) |
70.3 (PN2) 5.3 (PN8); 237.9 (PN5) |
74.4 (PN2) 29.1 (PN14); 243.4 (PN5) |
| Number of PN with <20% relative volume difference | 12 | 11 | 11 |
| B. INTERVAL CHANGES | Time-point 1 to 2 | Time-point 2 to 3 | Time-point 1 to 3 |
|---|---|---|---|
| MGH-3DQI - NCI-3DQI | |||
| Difference in % change Median (range) - % |
−1.7 (−20.0 to 26.7) P=0.56 |
1.1 (−49.7 to 14.9) P=0.80 |
−1.0 (−59.3 to 27.0) P=0.27 |
| Largest discrepancy in interval change - % (PN ID) | 63.7 vs. 37.0 (PN1) | 75.2 vs. 124.9 (PN14) | 180.5 vs. 239.7 (PN14) |
| Number of PN with <20% difference in interval change | 13 | 14 | 11 |
| Number of PN with concordant disease status assessment | 14 | 14 | 12 |
| NCI-3DQI - NCI-MEDx | |||
| Difference in % change Median (range) - % |
−2.3 (−11.2 to 11.2) P=0.60 |
3.3 (−11.0 to 12.4), P=0.095 |
−1.1 (−8.2 to 20.5) P=0.60 |
| Largest discrepancy in interval change - % (PN ID) | 65.7 vs. 54.5 (PN15) | 27.0 vs. 14.5 (PN3) | 109.9 vs. 89.4 (PN15) |
| Number of PN with <20% difference in interval change | 15 | 15 | 14 |
| Number of PN with concordant disease status assessment | 13 | 13 | 13 |
| MGH-3DQI - NCI-MEDx | |||
| Difference in % change Median (range) - % |
−0.4 (−31.2 to 26.4) P=0.68 |
2.0 (−45.9 to 14.4) P=0.39 |
−1.5 (−58.7 to 28.0) P=0.64 |
| Largest discrepancy in interval change - % (PN ID) | −10.5 vs. 20.7 (PN11) | 75.2 vs. 121.1 (PN14) | 180.5 vs. 239.1 (PN14) |
| Number of PN with <20% difference in interval change | 13 | 14 | 11 |
| Number of PN with concordant disease status assessment | 12 | 12 | 12 |
In large tumors, absolute volume differences tend to be greater, but in proportion to their size smaller lesions can have more measurement discrepancy, therefore we provide both the numeric and relative differences. The volume differences were calculated by subtracting one volume from the matching other, as listed in the header, and ranged from −781.9 ml (PN15, MGH3DQI vs NCI-MEDx, time-point 3) to 406.0 ml (PN1, MGH-3DQI vs. NCI-3DQI, time-point 2). Relative volume differences were calculated using the absolute volume differences between the matching pairs (irrespective of negative or positive values), and comparing to the mean of the same pairs. PN ID refers to the lesion identification as listed in Table 1.