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. Author manuscript; available in PMC: 2019 Feb 1.

Published in final edited form as: Am J Psychiatry. 2017 Oct 3;175(2):150–158. doi: 10.1176/appi.ajp.2017.17040472

Effect of a single dose of ketamine on suicidal ideation. Means from multilevel, mixed effects, general linear model (subjects nested within studies), adjusting for baseline suicidal ideation and between-study effects. Outcomes are: (A) combined self-reported scale scores (N=144, k=8, chi-square=45.5, p<0.001 for overall group x time interaction); (B) Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR) item 12 (N=77, k=4, chi-square=32.5, p<0.001 for overall group x time interaction); and (C) Beck Depression Inventory (BDI) item 9 (N=67, k=4, chi-square=8.34, p=0.080 for overall group x time interaction); *p<0.05, **p<0.01, ***p<0.001. Error bars are 95% confidence intervals.

Effect of a single dose of ketamine on suicidal ideation. Means from multilevel, mixed effects, general linear model (subjects nested within studies), adjusting for baseline suicidal ideation and between-study effects. Outcomes are: (A) combined self-reported scale scores (N=144, k=8, chi-square=45.5, p<0.001 for overall group x time interaction); (B) Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR) item 12 (N=77, k=4, chi-square=32.5, p<0.001 for overall group x time interaction); and (C) Beck Depression Inventory (BDI) item 9 (N=67, k=4, chi-square=8.34, p=0.080 for overall group x time interaction); *p<0.05, **p<0.01, ***p<0.001. Error bars are 95% confidence intervals.