Table 2.

Baseline Associations between ADM, BDI Total Score to CRP and IL-6

ADM USE	N	Median CRP* mg/dl (IQR)	N	Median IL6 pg/ml (IQR)
No	3001	0.36 (0.16, 0.73)	2966	1.92 (1.28, 2.95)
Yes	181	0.61 (0.34, 1.0)	179	2.01 (1.26, 3.19)

BDI ≥11	N	Median CRP mg/dl (IQR)	N	Median IL6 pg/ml (IQR)
No	2855	0.36 (0.16, 0.74)	2822	1.88 (1.26, 2.93)
Yes	327	0.44 (0.19, 0.98)	323	2.10 (1.54, 3.40)

ADM=Antidepressant medication use; BDI = Beck Depression Inventory total score; CRP = C-reactive protein; IL6= Interleukin 6; and IQR=Interquartile Range.

^*p = 0.01 for the association of log transformed CRP and ADM use adjusted for age at randomization, BMI, sex, race/ethnicity, triglycerides, smoking, HOMA-IR, fasting glucose, BDI score, treatment group, anti-inflammatory medications, estrogen, systemic steroids, and statins in the linear regression analysis.