Table 5.
Analysis of genotypic association between TFPI SNP rs10931292 and CAD under three different genetic models.
| Population (n, case/control) | Genetic model | Before adjustment | After adjustment | ||
|---|---|---|---|---|---|
|
| |||||
| Pobsa | OR (95%CI) | Padjb | OR (95%CI) | ||
| Overall CAD (4479/3628) | Additive | 0.089 | 1.06 (0.99–1.13) | 0.088 | 1.06 (0.99–1.14) |
| Dominant | 0.826 | 1.01 (0.92–1.11) | 0.618 | 1.03 (0.93–1.13) | |
| Recessive | 0.001 | 1.25 (1.09–1.44) | 0.005 | 1.23 (1.06–1.42) | |
| Early-onset CAD (700/3628) | Additive | 0.944 | 1.00 (0.89–1.14) | 0.644 | 1.04 (0.90–1.20) |
| Dominant | 0.428 | 1.07 (0.91–1.26) | 0.061 | 1.21 (0.99–1.46) | |
| Recessive | 0.167 | 1.19 (0.93–1.53) | 0.049 | 1.35 (1.00–1.81) | |
| Female CAD (1698/1329) | Additive | 0.524 | 1.04 (0.93–1.15) | 0.634 | 1.03 (0.92–1.16) |
| Dominant | 0.625 | 1.04 (0.89–1.21) | 0.804 | 1.02 (0.87–1.20) | |
| Recessive | 0.038 | 1.27 (1.01–1.60) | 0.169 | 1.19 (0.93–1.52) | |
| Male CAD (2707/2242) | Additive | 0.058 | 1.09 (1.00–1.18) | 0.079 | 1.08 (0.99–1.18) |
| Dominant | 0.424 | 1.05 (0.93–1.18) | 0.409 | 1.05 (0.93–1.19) | |
| Recessive | 0.006 | 1.28 (1.07–1.53) | 0.016 | 1.25 (1.04–1.50) | |
Pobs, observed P value (X2 test); Padj, P value after adjustment for covariates (logistic regression analysis by adjusting for gender and age); OR, odds ratio; 95% CI, 95% confidence interval; Early-onset CAD, males age 50 years or younger; females age 55 years or younger at the first diagnosis of the disease; Additive model = GG/AG/AA; Dominant model = GG+AG/AA; Recessive model = GG/AG+AA.