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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Trends Cell Biol. 2017 Nov 2;28(2):113–127. doi: 10.1016/j.tcb.2017.10.001

Figure 1. Domain structure and functions of human YTH proteins.

Figure 1

Schematic representation of domains and disordered regions of human YTH proteins: DF1, DF2, DF3, DC1, and DC2. DF1, DF2, and DF3 together make the YTHDF (DF) family. DC2 and the DF family proteins have a C-terminal YTH domain (pink), while DC1 has an internal YTH domain. All the proteins have low-complexity disordered regions (green). Disordered regions were identified using D2P2 database tools [80]. Additional domains in DC2 include R3H, DEXDc, ankyrin repeats (ANK), HELICc, HA2 and OB-fold domains. Protein length (in amino acids) is indicated next to each protein schematic. Functions of the human YTH proteins along with their alias names and major cellular localization are also indicated in a table (bottom panel).