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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Cell Immunol. 2017 Aug 1:S0008-8749(17)30120-X. doi: 10.1016/j.cellimm.2017.07.012

Figure 1. Effects of TLR stimulation on systemic expression of and humoral immune responses to hFIX as a function of time after muscle-directed gene transfer.

Figure 1

Comparison of systemic hFIX antigen (A) and IgG1 anti-hFIX (B) levels in C57Bl/6 mice after intramuscular co-injection of 1011vg AAV1-hFIX and 50 µg of indicated TLR agonist. (Data represent averages +/−SEM for n=3–4 mice per cohort; *P<0.05 AAV1+TLR9 v. AAV1 only). Experiement was repeated at least twice.