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. 2017 Aug 2;24(10):1288–1300. doi: 10.1177/1352458517721356

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© The Author(s), 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — MS risk factors, genetic variation in the VMP1 gene and smoking, do not affect DNA methylation in the VMP1/MIR21 locus. DNA methylation levels (β-values) in the VMP1/MIR21 locus, exemplified by cg07181702, do not associate with the MS risk genotype at RS8070345 (T = risk allele) in a (a) large cohort of healthy individuals or (b) in the Swedish cohort. Detailed analysis of the locus is given in Tables 3 and 4. (c) DNA methylation levels (β-values) in the VMP1/MIR21 locus, exemplified by cg07181702, are not affected by the smoking status in a large cohort of healthy individuals. Detailed analysis of the locus is given in Table 3.