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. 2017 Aug 2;24(10):1288–1300. doi: 10.1177/1352458517721356

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© The Author(s), 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — DNA methylation in the VMP1/MIR21 locus displays significant negative correlation with miR-21 expression, and RR-MS patients display lower miR-21 levels. DNA methylation levels (β-values) in the VMP1/MIR21 locus, exemplified by cg07181702, display a significant strong anti-correlation with (a) miR-21 levels but not with (b) VMP1 levels in CD4+ T cells from RR-MS, SP-MS and healthy controls (HC). Accordingly, RR-MS patients have lower levels of miR-21 compared to HC and SP-MS patients in the (c) 450K cohort and in an (d) independent validation cohort from Sweden. Detailed analysis of the locus is given in Table 5.