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. 2018 Jan 1;8(1):16–29.

Figure 7.

Figure 7

The combination of forskolin and bortezomib inhibits myeloma tumor growth in vivo. A xenograft MOPC315 MM mouse model was established, in which mice were administered with forskolin (5 mg/kg/d, i.p.), bortezomib (0.8 mg/kg, twice a week, i.v.), or their combination for two weeks. A. Tumor volume; B. Tumor weight; C. Consecutive measurement of tumor volume; D. Body weight of mice; E. Hematoxylin-eosin staining for histology, the expression of PCNA, TUNEL, cyclinD1, and Mcl-1 were analyzed by immunohistochemistry (IHC). ***P < 0.001. Scale bar = 50 μm.