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. 2018 Jan 1;8(1):70–80.

Figure 2.

Figure 2

Inhibition of Rac impairs acute colitis in mice. A. Western blotting analysis of Rac1, Rac2 and Rac3 expression in colonic tissue of acute colitis mice. GAPDH was used as a loading control. B. The relative expression of Rac1, Rac2 and Rac3 was analyzed. n=3, **, P<0.01. C. Schema of acute colitis model and EHT-1864 treatment. D. The representative macroscopic photos of colon after DMSO or EHT-1864 injection in acute colitis mice. E. Colon length of acute colitis mice. n=6, **, P<0.01. F. Hemoccult of acute colitis mice. n=6, **, P<0.01. G. Stool consistency of acute colitis mice. n=6, **, P<0.01. H. HE staining of colonic tissue of acute colitis mice. The histologic score was calculated and analyzed. n=5, **, P<0.01. I. ELISA analysis of IL-6, TNF-α, INF-γ and IL-1β expression in colonic tissue of acute colitis mice. n=3, **, P<0.01.