Inhibition of Rac impairs chronic colitis in mice. A. Schema of chronic colitis model and EHT-1864 treatment. B. The representative macroscopic photos of colon after DMSO or EHT-1864 injection in chronic colitis mice. C. Colon length of chronic colitis mice. n=6, **, P<0.01. D. Hemoccult of chronic colitis mice. n=6, **, P<0.01. E. Stool consistency of chronic colitis mice. n=6, **, P<0.01. F. HE staining of colonic tissue of chronic colitis mice. The histologic score was calculated and analyzed. n=5, **, P<0.01. G. ELISA analysis of IL-6, TNF-α, INF-γ and IL-1β expression in colonic tissue of chronic colitis mice. n=3, **, P<0.01.