Table 1.

The effects of crizotinib (C), palbociclib (P), and sex (S) on body and organ weight values (g) of CD-1 mice at 24 hours

	No C				C (4 mg)					P-value
	No P		P (1 mg)		No P		P (1 mg)
Item	F2	M	F	M	F	M	F	M	SEM3	S	C	S × C	P	S × P	C × P	S × C × P
n	5	5	5	5	5	5	5	5	-	-	-	-	-	-	-	-
Pre-Dose BW4	48.40	50.66	47.36	49.18	54.26	54.62	46.96	52.92	3.89	0.35	0.24	0.84	0.30	0.64	0.56	0.59
Post-Dose BW	46.06	49.60	45.08	46.68	52.54	53.24	45.92	51.48	3.75	0.29	0.15	0.92	0.26	0.78	0.68	0.53
Liver	2.64	2.60	2.68	2.02	2.38	2.42	2.04	2.98	0.33	0.77	0.90	0.08	0.73	0.77	0.42	0.11
Kidney	0.92	0.78	0.50	0.68	0.50	0.68	0.48	1.24	0.24	0.17	0.98	0.20	0.98	0.20	0.13	0.71
Spleen	0.56	0.12	0.16	0.14	0.18	0.12	0.12	0.62	0.24	0.98	0.93	0.20	0.93	0.16	0.24	0.84

¹Mice were treated with or without C and P 24 hours prior to the post-dose weighting of mice.

²F = female, M = male.

³Largest standard error of the mean (SEM) among treatments.

⁴BW = Body Weight (g).