Table 6.
The effects of crizotinib (C), palbociclib (P), and sex (S) on serum hematology values of CD-1 mice at 7 days
| No C | C (4 mg) | P-value | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| No P | P (1 mg) | No P | P (1 mg) | |||||||||||||
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| Item | F2 | M | F | M | F | M | F | M | SEM3 | S | C | S × C | P | S × P | C × P | S × C × P |
| n | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | - | - | - | - | - | - | - | - |
| WBC | 3.8 | 5.6 | 8.3 | 7.4 | 6.3 | 6.2 | 6.5 | 8.2 | 1.16 | 0.47 | 0.41 | 0.81 | 0.002 | 0.72 | 0.11 | 0.13 |
| RBC | 11.9 | 12.8 | 11.2 | 11.8 | 11.3 | 12.2 | 13.1 | 12.0 | 0.86 | 0.60 | 0.59 | 0.37 | 0.99 | 0.21 | 0.08 | 0.44 |
| Hemoglobin | 18.4 | 18.6 | 16.5 | 17.4 | 16.8 | 18.5 | 19.5 | 17.3 | 1.13 | 0.85 | 0.61 | 0.51 | 0.53 | 0.18 | 0.07 | 0.12 |
| Hematocrit | 66.1 | 67.8 | 59.3 | 64.3 | 59.9 | 68.5 | 66.5 | 62.5 | 4.14 | 0.35 | 0.99 | 0.81 | 0.26 | 0.29 | 0.21 | 0.13 |
| Platelet | 314.3 | 340.2 | 732.9 | 304.7 | 533.5 | 196.1 | 178.8 | 354.6 | 161.3 | 0.23 | 0.22 | 0.48 | 0.58 | 0.86 | 0.10 | 0.02 |
1Mice were treated with or without C and P 7 days prior to the collection of a single blood sample for the measurements of hematology values.
2
F = female, M = male.
3
Largest standard error of the mean (SEM) among treatments.