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. 2018 Feb 1;8:2110. doi: 10.1038/s41598-018-20343-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Weight and activation coefficients of the muscle synergies during the task in free space without external forces. (A) Weight coefficients for all muscle synergies (W1 to W5). Weight coefficients are shown for the two arms (dark: Dominant (D) and light: non-dominant (ND)). Control subjects (C) and MS subjects (MS) are shown with different colors as indicated in the legend. The error bars represent the standard error. (B) The green and red line represents the mean activation profiles for control subjects and MS subjects, respectively, for the five synergies (H1 to H5) in the dominant (D, first panel) and non-dominant (ND, second panel) arm. The shaded area indicates the standard error.