Table 2.

Biophysicals properties of WT, R1451C and R1451L channels at 10 °C.

	WT		R1451C		R1451L
	Mean ± sem	n	Mean ± sem	n	Mean ± sem	n
Steady-state activation		11		8		9
V1/2	−22.5 ± 1.6		−16.5 ± 2.7*		−14.7 ± 1.3**
kv	−8.4 ± 0.2		−10.6 ± 0.3***		−12.4 ± 0.7***
Steady-state inactivation		10		8		7
V1/2	−79.7 ± 1.4		−86.4 ± 2.8*		−97 ± 1.2***
kv	5.7 ± 0.3		10 ± 0.9***		10.2 ± 0.2***
Recovery from fast inactivation		5		8		6
τslow	4.4 ± 0.2		4.3 ± 0.3		3.3 ± 0.3*

V_1/2, midpoint for activation or inactivation (mV); k, slope factor for activation or inactivation; τ, time constant (ms); A, fraction of the τ components (%); n, number of cells. Values are means ± sem, *P < 0.05, **P < 0.001, ***P < 0.001, data were significantly different for mutant channels when compared to WT at 22 °C.