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. 2018 Feb 1;8:2043. doi: 10.1038/s41598-018-20217-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SMARCA4 is overexpressed, and SMARCA2 is underexpressed, in multiple types of tumors. (a,b) Volcano plots of SMARCA4 (a) or SMARCA2 (b) expression change (log₂(FC)) in tumors with respect to normal samples versus significance (−log₁₀(P value)), from different datasets. Data were obtained from ONCOMINE. Datasets with changes of P > 0.01 were not included. Highly significant changes (P ≤ 0.0001 and |FC| ≥ 2) are highlighted in orange and listed in Supplementary Tables S1 and S2. (c,d) Boxplot of levels of SMARCA4 (c) or SMARCA2 (d) mRNA (RNA-seq data) in normal or tumor samples of 22 different tumor cohorts from TCGA. Names and number of tumors and normal samples are listed in Supplementary Table S3. Significant Student’s t-test P value (P ≤ 0.05) are depicted in red.