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. 2018 Feb 1;8:2043. doi: 10.1038/s41598-018-20217-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome changes associated with SMARCA4 or SMARCA2 upregulation in KIRC. Ranking (x-axis) of KIRC tumor samples according to SMARCA4 (a) or SMARCA2 (c) expression (normalized RNA-seq data) (y-axis). Dots corresponding to the upper or lower decile are depicted in red or blue, respectively. (b) PC analysis of transcriptomic data from ten SMARCA4-high (red) and ten SMARCA4-low (blue) tumors. (d) PC analysis of transcriptomic data from ten SMARCA2-high (red) and ten SMARCA2-low (blue) tumors. (e,f) BP-GO categories enriched in SMARCA4-high (e) or SMARCA2-high (f) upregulated genes. s.t. signal transduction. (g,h) Overlapping between SMARCA2-high upregulated genes and mesangial cells-specific genes from two independent studies⁶⁶: (g) and⁶⁷ (GSE92650) (h). (i) BP-GO categories enriched in SMARCA2-high downregulated genes. (j) Overlap between SMARCA2-high downregulated genes from LIHC and KIRC tumors. (g,h,j) P values of the hypergeometric test. (k) BP-GO categories enriched in genes overlapping between SMARCA2-high upregulated genes from LIHC and from KIRC tumors. (e,f,i,k) Significance of the enrichments are given as the P values of the hypergeometric test (−log₁₀ transformed).