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. 2018 Feb 1;8:2135. doi: 10.1038/s41598-018-20566-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of hemoglobin level, platelet count, and soluble CD40L level, in cynomolgus monkeys with collagen-induced arthritis. Graphs of hemoglobin levels, platelet counts, and soluble CD40L levels. The time point of primary treatment is marked by the black arrow. Soluble CD40L levels are expressed as the mean ± SEM (n = 4 per group). The means of groups at each time points were compared using student t-tests. The paired t-test (†) was used to compare means from two related samples (before vs. after therapy). “*” and “^†”Indicate significant differences (p < 0.05). Control: control group; Anti-CD154: anti-CD154 treatment group; sCD40L: soluble CD40 ligand.