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. 2018 Feb 1;8:2135. doi: 10.1038/s41598-018-20566-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathology of the proximal interphalangeal joints and lungs from arthritic monkeys. (A) Articular cartilage sections were stained with Safranin O. Proximal interphalangeal joints from the forepaws of RA8 (control group) and RA7 (anti-CD154 group) and from the hind feet of RA8 (control group) and RA1 (anti-CD154 group) are presented (Original magnification: 12.5x and 40x). Treatment with anti-CD154 antibody resulted in a reduction in cartilage damage of the arthritic monkeys that had a high score for soft tissue swelling. (B) Lung tissue sections were stained with H&E. Lung tissues from RA8 (control) and RA7 (anti-CD154) are presented (Original magnification: 100x and 200x). Irregular thickening of the arterial intima layer was observed in lungs from the monkeys in both the anti-CD154 group and the control group. Control: control group; Anti-CD154: anti-CD154 treatment group; hand: forepaw; foot: hind foot; PIP: proximal interphalangeal joints.