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. 2018 Feb 1;8:2071. doi: 10.1038/s41598-018-20311-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BS induces the intrinsic apoptotic pathway in NCI-H460 cells. (a) Light microscopic images of NCI-H460 cells after 72 h treatment of BS. (b) Expression of active caspases and PARP cleavage under BS induced condition on NCI-H460 cells. Significant up-regulation of caspase-3, caspase-9 and PARP cleavage indicated activation of apoptotic pathway upon BS treatment. (c) The expression level of mitochondrial mediated apoptotic regulators after 72 h time of BS exposure (d) The protein levels of p53, P-p53, p21 were evaluated by western blot analysis. The gel blots were cropped from different gels and the full length blots are given in the supplementary file.