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. 2018 Feb 1;8:2062. doi: 10.1038/s41598-018-20428-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Single-unit spike recording analysis in the context of VPLo-HFS. (A) Microelectrode recordings were performed in the cerebellar receiving area of thalamus (VPLo) while stimulating in the same thalamic nucleus. (B) Recording artifacts were template-subtracted, with stimulation times used to generate peristimulus time histograms (PSTHs) of spike activity. Spike depolarization is shown as a negative polarity. (C) PSTHs from a recorded neuron before and during HFS at three different stimulation amplitudes. $Δ H$ is the percentage decrease in PSTH entropy between the HFS-off and HFS-on states. The $p$ value indicates the likelihood of the observed PSTH entropy during HFS to occur by chance.