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. 2018 Feb 1;8:2062. doi: 10.1038/s41598-018-20428-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heterogeneity of thalamic PSTH responses to VPLo-HFS with increasing stimulation amplitude. (A–F) Representative examples of the following classes of responses (p: firing pattern modulation, r: firing rate modulation. ‘+’: increase in firing rate or phase-locked spike activity, ‘−’: decrease in firing rate or phase-locked spike activity, n: no response). (G–J) Dependence of stimulation amplitude on motor thalamic neuronal responses to VPLo-HFS. Data from Subject K and Subject U are on the left and right side of the legend, respectively. The top row shows the proportionate effects of HFS at 150, 250, and 350 $μ A$ across all recordings (Subject K: n = 245, Subject U: n = 283), whereas the bottom row shows the corresponding percentages only for those recordings that were significantly modulated by HFS (i.e. firing pattern or rate modulation). (K,L) Effect of stimulus amplitude on all cells exhibiting one or more instances of firing pattern modulation (n = 11 cells in Subject K, n = 21 cells in Subject U).