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. 2018 Feb 1;8:2062. doi: 10.1038/s41598-018-20428-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of HFS amplitude on PSTH entropy change and firing pattern modulation. (A,B) Shown are population-based entropy changes in those cells with at least one significant entropy change amongst the three stimulus amplitudes. NS: no significant difference by multiple comparison test. *Significant difference by Mann-Whitney U test with Bonferroni correction (α = 0.0167, FPM cells: Subject K, n = 21 recordings; Subject U, n = 32 recordings). (C) Likelihood of firing pattern modulation to occur across the three different stimulus amplitudes.