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. 2018 Feb 1;8:2062. doi: 10.1038/s41598-018-20428-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of modulated motor thalamic activity with respect to stimulation artifact size. Percent decrease in PSTH entropy between the HFS-off and HFS-on periods plotted against the peak amplitude of the recorded HFS artifact for (A) Subject K and (B) Subject U. Recordings that exhibited significant firing pattern modulation during HFS are labeled as large black solid circles. (C,D) Spatial distribution of neuronal recordings grouped by their response to HFS (p: firing pattern modulation, r: firing rate modulation. ‘+’: increase in firing rate or phase-locked spike activity, ‘−’: decrease in firing rate or phase-locked spike activity, n: no response). (E,F) Relationship between the stimulus artifact peak amplitude and the estimated recording site distance from the centroid point of the active DBS row. Shown are data for both subjects categorized based on stimulus amplitude (150, 250, and 350 µA).