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. 2018 Feb 1;8:2158. doi: 10.1038/s41598-018-20538-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of Sfi1 mRNA in the PFC and hippocampus from the adult offspring after prenatal poly(I:C) exposure and expression of SFI1 protein and SFI1 mRNA in schizophrenia. (a) Schedule of treatment and behavioral tests. Saline (5 ml/kg/day) or poly(I:C) (5.0 mg/kg/day from E12 to E17) was injected into pregnant mice. Normal food pellets or 0.1% GF food pellets were given to juvenile offspring from D28 to D56. Subsequently, normal food pellets were given to all mice for 14 days (D57-). Brain samples were collected at D70. (b): Sfi1 mRNA in the PFC: There was significant effects (poly(I:C): F_1,22 = 25.39, P < 0.001; GF: F_1,22 = 20.28, P < 0.001; interaction: F_1,22 = 45.97, P < 0.001). (c) Sfi1 mRNA in the hippocampus: There was significant effects (poly(I:C): F_1,22 = 9.29, P = 0.006; GF: F_1,22 = 6.65, P = 0.017; interaction: F_1,22 = 31.01, P < 0.001). The value is expressed as the mean ± S.E.M. (n = 5–7). ***P < 0.001 compared to poly(I:C) + control group. (d) Expression of SFI1 protein in the parietal cortex from patients (n = 15) with schizophrenia was significantly (P = 0.034) higher than that of controls (n = 15). The value is expressed as the mean ± S.D. *P < 0.05 compared to control group. (e) Expression of SFI1 mRNA in the hair-follicle from patients (n = 94) with schizophrenia was significantly (P = 0.002) lower than that of controls (n = 117). The value is expressed as the mean ± S.D. **P < 0.01 compared to control group.